What is your personal "Meet Hanako at Embers" but for other main missions?

Mine is Automatic love- Enter Megabuilding H8. As soon as i talked to Judy i just went round doing NCPD subcons and gigs until my map is clean of them while visiting every weapon store to buy the crafting schematics. All thats left is the desert. Had the same problem with the Witcher 3. Ignored the main quest until all those questions marks were gone