Ideas, Inspiration, and Insight, please!

I mentioned this in a comment, but now I am certain I want to do it. In respect of Legacy, I have decided I wish to stake my place in this community by making my very own sprite comic. The sad part is, however, I lack everything I need to do such a thing because I don't know how you guys do it!

I know how to sprite though a handy site called PISKEL, but I have no idea what you guys use to put scenes together neatly. I also don't know WHAT I'd make a story about (I have one idea regarding Axis but idk if you guys would like it.)

..Any insight on my predicament would be handy. Also, I hope whatever info you guys possibly provide could help someone else in my same situation in the future. Thank you all.