Gimmick for the Sequel
When Codename Orion releases at some point, it'll likely have some sort of tantalizing hook for the plot or marketing that drives the game and separates it from its predecessor (I don't mean the existence of a plot, but more of a specific macguffin to chase or drive the plot). For example, 2077 had the Relic/Johnny, a comparable game in Skyrim had dragons returning, Witcher 3 had the Ciri rescue/Wild Hunt, and so on. Not to say that the sequel, or any game, needs a macguffin to drive a plot, but realistically, there will be *some* kind of bananas sci-fi item, conflict, or so on that makes things especially tense or time-sensitive. Something that's the "oh wow" moment in an early trailer. So, what would you be interested to see drive a plot in Orion?
One that stuck out to me is if a close friend, family member, etc. (but not love interest because you need those juicy romance options) was Soulkilled. Their body might be with you, or with a corp, or destroyed, but their mind, for some reason, is trapped in a nightmarish computer to serve corpo interests for all time, and you need to find a way to free them (if possible) or at least to purge them so they don't suffer for eternity. Similar to what happened to Alt, or what you may try to save Songbird from, but different enough to avoid being a retread, and it being the driving force for you in the game, both to infiltrate whatever holds them, and determining how to save or purge them if you do make it there.
Otherwise, some items that come to mind are:
A corpo or war (and Kingmaking which side wins, or if government borders change, etc).
Pretty much anything Morgan Blackhand or involving the other side of the Blackwall.
Any sort of groundbreaking technology that involves a hunt for it, but I think this would retread the Relic's plot too much, even if it was technology like controlling satellites, neural processors or netrunning on entirely new levels, etc.
Proper cloning or other Biotechnica developments that create interesting moral questions and hunts to steal, accelerate, or stop this technology.
V as a key character or antagonist. Whether playing a Rogue role as a vet fixer or questgiver, the Revan role from KOTOR (iykyk), a clone/improper duplicate (tying into the above Biotechnica idea) that a corp generates and uses as Adam Smasher-esque muscle, or takes control of a faction on his/her own (I like the "not the actual V" more as it leaves canon endings and characteristics of V up to you, obviously they'd have to be really careful about including V in a sequel for that reason)
The player character having a really specific and interesting life goal, that differs from V/Jackie's desire to be a merc. You want to solve a crime that impacted you personally (overused trope, but they could be creative), you want to be a realllllly famous rockerboy (honestly, could be a fun plotline). You want to take over a corp (for the money, for the power, to improve the corp's ethics and impact on the world? To destroy the corp from the inside? Up to you) but the road or handshake deal to getting that position costs a lot, maybe more than you're willing to pay.
Tied to the above, maybe the player character despises Night City to no end for what it's done to you and others, and your quests that impact what it looks like (like the mayor campaign quest in 2077, certain gangs getting stronger or weaker, etc) and ultimately having a choice at the end of the game, is Night City redeemable and on a path to light, or do you clean it out, League of Shadows-style, with a nuke, other technology, or upping the crime and corruption even more, to a point that everything truly collapses. Make Johnny Silverhand look like Gandhi.
TLDR: Any sci-fi world, Cyberpunk included, has a million possible macguffins or gimmicks to theme a game around. What would you want to be the Relic, "gotta save Ciri (or play Gwent)," etc. for Cyberpunk 2077.2, Electric Cyberloo?